Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-XL and Hrk.

بررسی اثر کلستاز و داروی نورواید بر بیان ژن -Bcl-xl در ناحیه هیپوکمپ موش‌های صحرایی نر

Background and Objective: Cholestasis is bile duct obstruction with accumulation of toxic bile acids in liver and circulatory systems and increased toxicity in hepatocytes. Some studies have shown that cholestasis induces spatial memory deficit. Hippocampus plays an important role in this process. In this research, the effect of cholestasis on expression of BCL-XL (B-cell lymphoma-extra large&n...

Effect of rosemary essential oil on the expression of BCL-XL, an anti-apoptotic gene, in MCF-7 cell line breast cancer

Effect of valproic acid on JAK/STAT pathway, SOCS1, SOCS3, Bcl-xL, c-Myc, and Mcl-1 gene expression, cell growth inhibition and apoptosis induction in human colon cancer HT29 cell line.

Background and aim: Cytokines are a large family of protein messengers. These proteins induce various cellular responses. Janus kinases (JAKs) are mediators of cytokine, activated JAKs phosphorylate signal transducers, and activators of transcription (STAT) proteins that regulate cell differentiation, proliferation, and apoptosis. Aberrant JAK/STAT signaling is involved in the oncogenesis of se...

The effects of nitric oxide production blockage by aminoguanidine on passive avoidance memory and expression of Bcl-2 family genes in diabetic rats

Introduction: Memory impairment is one of the complications of diabetes which may accompany with changes in expression of apoptotic and antiapoptotic genes. The aim of the present study was the evaluation of intra-hippocampal injection of aminoguanidine (AG), as an antioxidant and inducible nitric oxide synthase inhibitor, on passive avoidance memory and Bcl-2 family genes expression in diab...

Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine

BACKGROUND Leishmaniasis is the world's second deadliest parasitic disease after malaria, and current treatment of the different forms of this disease is far from satisfactory. Alkylphospholipid analogs (APLs) are a family of anticancer drugs that show antileishmanial activity, including the first oral drug (miltefosine) for leishmaniasis and drugs in preclinical/clinical oncology trials, but t...